RETROSPECTIVE ANALYSIS OF MALIGNANT MIXED MULLERIAN TUMOUR FROM A TERTIARY CARE CENTER IN INDIA

Dr.Manivannan.P

Final year PG

Dept of Medical Oncology

MMC, Chennai

DR.MANIVANNAN.P, DR.KALAISELVI.K, DR.RAJA.G, DR.SURESH KUMAR.S

BACKGROUND: Malignant Mixed Mullerian tumour (MMMT) also  called as carcinosarcoma , is an extremely rare and aggressive tumour which accounts for less than 5% of all uterine malignancies. These tumours are usually associated with poor outcomes. There is pancity of data regarding this uncommon Malignancy.

OBJECTIVE: To evaluate the clinical profile, outcomes and  survival of patients with MMMT treated with multimodality treatment.

METHOD: A five year retrospective analysis of cases diagnosed as MMMT and treated in a tertiary care centre were analysed. Eighteen patients with pathological proven diagnosis of MMMT treated at our institute from January 2014 to December 2018 were analysed. These patients had undergone comprehensive surgical staging followed by adjuvant chemotherapy/ radiotherapy.

RESULTS: A majority of these patients presented with postmenopausal bleeding and denominal pain. Median age at presentation was 60 yrs. Out of 18 patients, 14 underwent complete surgery and 4 were inoperable and ended up only with debulking. Adjuvant therapy was given to 14 patients, out of which 2 patients had defaulted and among the others 7 patients had received chemotherapy, 4 patients received radiotherapy and one patient underwent chemoradiation. Outcomes of the patients were poor inspite of chemotherapy /radiotherapy.

CONCLUSION: MMMT is an aggressive tumour with poor outcomes. The optimal adjuvant therapy for such aggressive tumours is yet to be established which would result in better survival.

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